broad spectrum sstr antagonist tocris cat Search Results


293t  (ATCC)
99
ATCC 293t
293t, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cyclosomatostatin  (Bio-Techne corporation)
93
Bio-Techne corporation cyclosomatostatin
Cyclosomatostatin, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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selective sstr1 agonist ch275  (Tocris)
90
Tocris selective sstr1 agonist ch275
Selective Sstr1 Agonist Ch275, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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broad spectrum sstr antagonist tocris cat#3493  (Tocris)
90
Tocris broad spectrum sstr antagonist tocris cat#3493
Broad Spectrum Sstr Antagonist Tocris Cat#3493, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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broad-spectrum sstr antagonist tocris cat#3493  (Tocris)
90
Tocris broad-spectrum sstr antagonist tocris cat#3493
Broad Spectrum Sstr Antagonist Tocris Cat#3493, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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glp-2 tocris  (Tocris)
90
Tocris glp-2 tocris
Glp 2 Tocris, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cyclo-sst  (Tocris)
90
Tocris cyclo-sst
Cyclo Sst, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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somatostatin (sst  (Millipore)
90
Millipore somatostatin (sst
A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM lysophosphatidic acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM <t>somatostatin</t> (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.
Somatostatin (Sst, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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somatostatin  (Bio-Techne corporation)
94
Bio-Techne corporation somatostatin
A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM lysophosphatidic acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM <t>somatostatin</t> (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.
Somatostatin, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/somatostatin/product/Bio-Techne corporation
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lysophosphatidic acid (lpa  (Millipore)
90
Millipore lysophosphatidic acid (lpa
A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM <t>lysophosphatidic</t> acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.
Lysophosphatidic Acid (Lpa, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse monoclonal anti gabab receptor  (NeuroMab)
90
NeuroMab mouse monoclonal anti gabab receptor
A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM <t>lysophosphatidic</t> acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.
Mouse Monoclonal Anti Gabab Receptor, supplied by NeuroMab, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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l-glutamic acid  (Millipore)
90
Millipore l-glutamic acid
A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM <t>lysophosphatidic</t> acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.
L Glutamic Acid, supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM lysophosphatidic acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.

Journal: bioRxiv

Article Title: Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

doi: 10.1101/2021.04.08.435504

Figure Lengend Snippet: A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM lysophosphatidic acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.

Article Snippet: Compounds used were: lysophosphatidic acid (LPA; Sigma, cat#L7260), α-latrotoxin (Enzo Life Sciences, cat#50-200-9609), Slit guidance ligand 2 (SLIT-2-N; Sigma, cat#SRP3155), prostaglandin E 2 (PGE2; Tocris, cat#2296), somatostatin (SST; Sigma, cat#S9129), glucose-dependent insulinotropic polypeptide (GIP; Eurogentee, cat#AS-65568), L-glutamic acid (Sigma, cat#G1251), and epinephrine (Sigma, cat#E4375).

Techniques: Immunostaining, Sequencing, Expressing

A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM lysophosphatidic acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.

Journal: bioRxiv

Article Title: Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

doi: 10.1101/2021.04.08.435504

Figure Lengend Snippet: A) Outline of an expanded dataset of electrically profiled human islet cells, and tSNE representations of α- and β-cells identified by immunostaining or sequencing along with the relative distribution of Na + current half-inactivation values. B-C) The distribution of Na + current amplitudes (B) and voltage-dependence of half-inactivation values (C) demonstrate significant heterogeneity and overlap between β-cell ( light blue ) and α-cell ( pink ) populations. D) Correlation between α-cell peak Na + current and transcript expression reveals several significant positive ( green ) and negative ( red ) correlations, some of which are mapped here (see also Suppl Table 5 ). E) Correlation of α-cell peak Na + current and selected transmembrane signalling receptor transcripts (see also Suppl Fig 4 ). F) In separate donors, Na + currents measured with receptor agonists (colours matching receptors shown in panel E) upon depolarization from -70 to -10 mV. Peak current is shown at right: control (n=53 cells); 0.5 μg/ml SLIT-2-N (n=17 cells); 10 μM prostaglandin E 2 (PGE2, n=17 cells); 0.5 μM lysophosphatidic acid (LPA, n=14 cells); μg/ml α-latratoxin (n=24 cells); 10 mM L-glutamic acid (n=21 cells); 100 nM glucose-dependent insulinotropic polypeptide (GIP, n=7 cells); 200 nM somatostatin (SST, n=24 cells); 5 μM epinephrine (n=22 cells). Data were compared by one-way ANOVA, followed by the Benjamini and Hochburg post-test to method to compare groups controlling for false discovery rate. *-p<0.05 and ***-p<0.001 compared with control.

Article Snippet: Compounds used were: lysophosphatidic acid (LPA; Sigma, cat#L7260), α-latrotoxin (Enzo Life Sciences, cat#50-200-9609), Slit guidance ligand 2 (SLIT-2-N; Sigma, cat#SRP3155), prostaglandin E 2 (PGE2; Tocris, cat#2296), somatostatin (SST; Sigma, cat#S9129), glucose-dependent insulinotropic polypeptide (GIP; Eurogentee, cat#AS-65568), L-glutamic acid (Sigma, cat#G1251), and epinephrine (Sigma, cat#E4375).

Techniques: Immunostaining, Sequencing, Expressing